Rapid diagnosis of diseases at their initial stage is extremely important for effective clinical outcomes and promotes general public health. In recent years, numerous electrochemical biosensors have been developed and proposed for detection of various diseases taking advantage of their features, including selectivity, sensitivity, low cost and rapid response. Under the unremitting efforts of the staff in Creative Biolabs, the development technology of electrochemical biosensors has undergone a steady improvement with the lowered detection limits and the enlarged linear response range. Creative Biolabs now provides customized electrochemical biosensor development for various disease detection.
Immunosensors are a typical kind which are based on immunoassays. An immunosensor incorporates an antibody as the electrochemical recognition element and a transducer based on a light-sensitive material such as fiber optical sensors, surface plasmon resonance sensors and so forth. Based on the highly selective recognition of antibodies for antigens, immunosensors have been manufactured and are widely applied in monitoring diseases.
The DNA hybridization biosensor is another typical category of affinity biosensors which incorporates aptamer as the recognition components. DNA hybridization biosensors are widely used for diagnosis of genetic or infectious diseases. When preparing a DNA biosensor, the aptamer production is of vital importance (Aptamers in the Diagnostic Pipeline). Two ways are available to monitor the hybridization, namely label electrochemical measurements and label-free ones.
A biomarker is a characteristic indicator of some biological, pathogenic process, or pharmacological response to therapeutic intervention. The use of an appropriate biomarker that makes the detection procedure highly sensitive and selective is of vital significance. An electrochemical immunosensor is a typical device used for detection of these diseases, in which a sandwich immunoreaction is usually performed on an electrode surface, including a tracer antibody, a capture antibody and the antigen. It depends on whether there an inflammatory response or antigen-antibody reaction, which serves as a characteristic marker exists.
At Creative Biolabs, many efforts have been devoted to the improvement of electrodes, signal amplifiers and indicator labels. Modifying the electrode with various coatings and adopting advanced nanomaterials as well as proper indicators will influence the sensor performance. In the design process, the immobilization of biomolecules on the transducer surface is an important procedure. Creative Biolabs provides different immobilization techniques which may contribute to differing biosensor sensitivity and stability. Various materials including semiconductors, ceramics, metals, organic materials and metamaterials are optional in the manufacture of various types of sensors.
To our knowledge, antigens/antibodies, DNA/RNA series, enzymes are the most commonly used biomolecules for accurate detection of a variety of diseases. Creative Biolabs has made outstanding achievements in the following areas.
Electrochemical biosensors have been proved to offer advantages such as simplicity and cost-effectivity, and they exhibit good sensitivity and selectivity under optimized conditions. If you are interested in using electrochemical biosensor for disease detection research, please feel free to contact us for more information.
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