Creative Biolabs is a leading service provider that focuses on polyclonal, monoclonal, and recombinant antibody development for research, diagnosis, and potential therapeutics. Based on our extensive experience and state-of-the-art platforms, Creative Biolabs now offers a series of biomarker-specific IVD (in vitro diagnostic) antibody development services to clients globally. Especially, we introduce our IVD antibody development services for gamma-glutamyl transpeptidase marker.

Gamma-Glutamyl Transpeptidase

Gamma-glutamyltransferase (also known as γ-glutamyltransferase, GGT, or gamma-GT), is a transferase which catalyzes the transfer of gamma-glutamyl functional groups from molecules like glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). GGT is an enzyme in prokaryotes and eukaryotes and consists of two polypeptide chains, a heavy and a light subunit. The active site of GGT is identified to be located in the light subunit. GGT plays an essential role in the gamma-glutamyl cycle, which is identified as a pathway for the synthesis and degradation of glutathione as well as drug and xenobiotic detoxification. GGT has also been indicated to be able to play a pro-oxidant role with regulatory influences at various levels on cellular signal transduction and cellular pathophysiology.

GGT takes parts in the transfer of the amino acid and peptides across the cell membrane. Fig.1 GGT takes parts in the transfer of the amino acid and peptides across the cell membrane.

Diagnostic Utility of GGT in Kidney Disease

GGT exists in the cell membranes of many tissues, such as the kidneys, pancreas, bile duct, gallbladder, brain, heart, spleen, and seminal vesicles. It is responsible for the hydrolysis of extracellular reduced glutathione (GSH), one of the main intracellular antioxidants in mammals, allowing the precursor amino acids to be subsequently involved in new intracellular GSH synthesis. Consequently, elevated GGT is an expression of intracellular GSH depletion and thus GGT could be regarded as a marker of oxidative stress. Accordingly, it has great significance as a diagnostic marker in medicine. High serum gamma-glutamyl transferase (GGT) levels have been demonstrated being related to increased mortality in patients with chronic kidney disease (CKD). Based on numerous studies on GGT, GGT levels have been commonly found to be abnormally elevated in patients with CKD, especially in those with greater comorbidity such as cardiovascular diseases and is independently related with mortality.

Normal kidney and diseased kidney. Fig.2 Normal kidney and diseased kidney.

IVD Antibody Development Services Targeting GGT Marker

Based on the rapid development of IVD technology and novel biomarkers, IVD antibodies are extensively used for disease screening and therapeutic monitoring. Diverse immunoassays are applied, including lateral flow assay, immunochemistry, sandwich ELISA, etc. Through our role as a leading antibody service provider, Creative Biolabs is well-positioned to deliver high-quality IVD antibody development services targeting numerous biomarkers, such as GGT. With years of devotion and accumulation in this particular field, Creative Biolabs is confident in offering you the best products and services. For more detailed information, please feel free to contact us or directly send us an inquiry.

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