Introduction of GHSR
The growth hormone secretion promoting substance receptor (GHSR), also known as the G protein-coupled receptor of the ghrelin receptor that binds growth hormone secretagogues (GHSs), such as ghrelin. GHS-R1a belongs to the family of G protein-coupled receptors (GPCRs). The ghrelin binds to receptors that secrete growth hormone through the pituitary gland, and appetite-modulating factors secreted by peripheral organs. The role of GHSR is thought to be in regulating energy homeostasis and body weight.
|Basic Information of GHSR|
|Protein Name||Growth hormone secretagogue receptor type 1|
|Aliases||ghrelin receptor, GH-releasing peptide receptor|
|Organism||Homo sapiens (Human)|
Function of GHSR Membrane Protein
GHSR is involved in the secretion of GH, food intake and fat accumulation. The most important biological role of GHSR is shown by its combination with the ligand Ghrelin. GHS-R1a in pituitary cells stimulates pituitary glands to secrete growth hormone after binding to ghrelin. GHSR combined with Gerlin induces appetite or hunger. Moreover, the pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. The growth hormone secretagogue receptor may also be linked to learning and memory.
Fig.1 GHSR induced mechanism of signal transduction in relation to the IR.
Application of GHSR in Literature
This article reports that the direct interaction of ghrelin with GHSR attenuates glucose-induced insulin release; novel beta-cell-specific GHSR-cAMP/TRPM2 signaling provides a potential therapeutic target for the treatment of type 2 diabetes.
This article reveals that GHS-R ablation can regulate dietary patterns by regulating hypothalamic neuropeptides to regulate feeding behavior.
In this paper, it shows that GHS-R plays an important role in heat-induced damage during aging. GHSR antagonists can shift energy balance from obesity to heat production to fight obesity.
This article reports that GHSR up-regulates inflammatory cytokines and macrophage activation, which promotes the development of acute DSS-induced colitis and serves as a potential therapeutic target for IBD.
This article shows that the GHSR is enriched in the neurogenic niche of the hippocampal dentate gyrus (DG) and GHSR mediates the beneficial effects of CR on enhancing adult hippocampal neurogenesis and memory.
GHSR Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GHSR antibody development services.
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