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Anti-Membrane Protein Antibody Discovery Services by Hybridoma

Hybridoma technology has long been the classic approach and milestone for the generation of monoclonal antibodies. With years of experience in membrane protein production and antibody discovery, Creative Biolabs now provides anti-membrane protein antibody discovery services using hybridoma to our worldwide clients.

Membrane proteins, consisting of 20~30% of total encoding genes, make up over 50% of current therapeutic targets. Nowadays, anti-membrane protein antibody becomes more and more popular in clinical due to their high specificity, high affinity, and low cytotoxicity compared with small molecules. Creative Biolabs can offer different platforms to develop anti-membrane protein antibodies, including:

Anti-Membrane Protein Antibody Discovery Using Rat Hybridoma Anti-Membrane Protein Antibody Discovery Using Mouse Hybridoma
Rats are the ideal source for anti-membrane protein antibody discovery. Rat monoclonal antibodies offer several other advantages over mice.
  • The ability to induce the immune response to mouse antigens.
  • Rat antibodies pair better than those of mice in sandwich assays.
  • Rat antibodies do not have the cross-reaction in immune-detection of antigens out of a mouse background.
Mouse hybridoma technology is the most widely and successfully used approach for the production of mouse monoclonal antibodies.
  • Mice take advantages of their small size, lower feeding cost, ease of maintenance and handling, and strong ability to reproduce.
  • Mice share similar antibody isotypes with humans.

Advantages of Anti-Membrane Protein Antibody Discovery Using Hybridoma

As a dedicated service provider, Creative Biolabs is also professional in tailoring challenging membrane proteins in functional immunogen formats. With the help of our membrane protein preparation as antigen for antibody discovery service, multiple formats of membrane proteins including liposomes, polymers, nanodiscs, designed peptides, DNA immunization, whole cell presentation, etc. can be utilized for immunization and antibody selection. With our Ph.D. level science team and years of experience, plenty of GPCR immunogens, ion channel immunogens, and transporter immunogens have been successfully obtained. We are more than happy to facilitate your projects and push the progress towards pre-clinical trials. Please feel free to contact us for more details.


All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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