Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), also known as fructose transporter or glucose transporter type 5, small intestine (GLUT-5), is a protein in humans that is encoded by the SLC2A5 gene. It is a fructose transporter mainly expressed on the apical border of enterocytes in the small intestine.
| Basic Information of SLC2A5 | |
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 5 |
| Gene Name | SLC2A5 |
| Aliases | Fructose transporter, Glucose transporter type 5, small intestine, GLUT-5 |
| Organism | Homo sapiens (Human) |
| UniProt ID | P22732 |
| Transmembrane Times | 12 |
| Length (aa) | 496 |
| Sequence | MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT |
GLUT5 (SLC2A5) is a fructose transporter encoded by the SLC2A5 gene of the SLC2 family. It is primarily expressed in the jejunal region of the small intestine. Lower levels of the protein are found in kidney, brain, skeletal muscle, and adipose tissue. Studies have shown that it could mediate fructose absorption in the jejunum at the apical, potentially also basolateral membrane, of the epithelial cells into the portal vein. During the past years, the expression level of SLC2A5 is associated with numerous diseases. For example, the expression of SLC2A5 is elevated in breast cancer cell lines MCF7 and MDA-MB-231 and associated with higher fructose uptake rate. Recently, it has shown that the expression of SLC2A5 in tumor cells of patients with AML is increased and is negatively correlated with the prognosis of patients. Furthermore, SLC2A5 is significantly upregulated in lung adenocarcinoma patients and overexpression of SLC2A5 is highly correlated with poor patient survival.
Fig.1 Fructose promotes lung adenocarcinoma cell survival and metastasis through SLC2A5. (Weng, 2018)
This article suggests that SLC2A5 is significantly upregulated in lung adenocarcinoma (LUAD) patients and overexpression of SLC2A5 is highly correlated with poor prognosis of LUAD patients. It indicates that GLUT5 may be used as a potential target alone or in combination with other treatment for lung cancer therapy.
This article suggests that PPF MM represents a promising nanoscale carrier system to achieve GLUT5-mediated cell-specific delivery in cancer therapy.
This article aims to explore the possible roles of glucose transport 5 (Glut5) in imatinib resistance in the Ph+ acute lymphoblastic leukemia cell (Ph+ ALL). It finds that high expression of SLC2A5 and Glut5 protein in SUP-B15/R cells could lead to increased fructose absorption, and further activates the PI3K/AKT pathway which causes the SUP-B15 cell resistance to imatinib.
This article aims to determine the distribution of glucose transporter 5 (GLUT5), which preferentially transports fructose, in the rat brain by immunohistochemistry and western blotting. It suggests that GLUT5 may transport fructose in subsets of the glia and neurons for an energy source of these cells.
This article suggests that fructose and GluT5 play an important role in regulating adipose differentiation.
To provide high-quality products, we have developed an advanced Magic™ membrane protein production platform which enables us to provide numerous membrane protein products. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC2A5 antibody development services.
Based on extensive experience and professional scientists, Creative Biolabs is dedicated to promoting global customers’ programs. Except for SLC2A5 membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
