3D Ex Vivo Human Bladder Contraction and Relaxation Model Introduction

Step into the realm of 3D biology, Creative Biolabs has successfully developed 3D ex vivo human bladder contraction and relaxation model for global clients.

Bladder Contraction and Relaxation

The bladder's primary function is to store urine before voiding. Bladder relaxation is mediated by intrinsic smooth muscle properties and sympathetic nerve release of norepinephrine (NE), which activates β-adrenergic receptors in the detrusor muscle. Voiding is achieved by inhibiting sympathetic nerve input and activating release of acetylcholine (ACh) and ATP to contract the bladder smooth muscles, mediated by the parasympathetic nervous system.

Traditional Model for Bladder Contraction and Relaxation

The existing data on bladder function and the effects of drugs primarily rely on observations made in animals. However, direct extrapolation of animal data to humans is often not straightforward. The reason for this is that bladder relaxation and contraction in various animal species involve different subtypes of β-adrenergic receptors, which may not precisely mirror the situation in humans.

Fig 1. Neurophysiological modeling of bladder afferent activity in the rat overactive bladder model.¹

3D Ex Vivo Human Bladder Contraction and Relaxation Model

Creative Biolabs offers fresh functional bladder tissue derived from human sources to assess the effects of test compounds on bladder smooth muscle tone by triggering contraction/relaxation in vitro using ex vivo tissue.

This model, utilizing human-derived tissues, retains the original ion channels, receptors, and intracellular pathways, including the receptors, neurotransmitters, and pathological changes involved in drug stimulation as seen in vivo. The 3D human ex vivo model has been extensively employed for evaluating various tissues, organs, and drug structure-activity relationships, and has been extended to measure the effects of drugs on the release of outgoing/incoming neurotransmitters.

Our Services

Creative Biolabs has introduced an extensive and comprehensive 3D ex vivo human urinary system tissue model listed below for studying bladder contraction and relaxation. This advanced approach enables precise and detailed analysis of bladder function and drug effects, facilitating advancements in the field of bladder research. Particularly, we offer standardized compound testing protocols, which are developed based on EC/IC50 or pA2 testing. Our expert team possesses the expertise to detect bladder neurogenic contractions that are activated by electrical field stimulation. Connect with us today for more information about how we can assist your projects.

• 3D Ex Vivo Human Ureter Relaxation Model
• 3D Ex Vivo Human Urethra Contraction Model
• 3D Ex Vivo Human Bladder Tissue Model
• 3D Ex Vivo Human Kidney Tissue Model

Related Sections:

• Ex Vivo Human Genitourinary Tissue Model
• Ex Vivo Human Skin System Tissue Model
• Ex Vivo Human Urinary System Tissue Model
• Ex Vivo Neurological System Model
• Ex Vivo Human Digestive System Model
• Ex Vivo Human Musculoskeletal System Tissue Model
• Ex Vivo Human Respiratory System Tissue Model
• Ex Vivo Human Endocrine System Tissue Model
• Ex Vivo Human Cardiovascular Tissue Model