Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
Highlights| Protein Name | Arginine vasopressin receptor 2 |
| Gene Name | AVPR2 |
| Uniprot | P30518 (Human); O88721 (Mouse) |
| Synonym | DI1; DIR; NDI; V2R; ADHR; DIR3; AVPR V2; antidiuretic hormone receptor; renal-type arginine vasopressin receptor |
| Background | The AVPR2 is a member of the 7 membrane domain family of G protein-coupled receptors (GPCRs) and is a protein that acts receptor for vasopressin. The activity of the AVPR2 receptor is mediated by the Gs type of G proteins, which stimulates adenylate cyclase. It activates the Gs protein via its third intracellular loop i3 and part of its proximal C-terminal region to produce its renal antidiuretic effect. AVPR2 is predominantly expressed on the basolateral membrane of the distal convoluted tubule and collecting ducts of the kidney. |
Creative Biolabs offers comprehensive range of membrane protein products empowers your unique research needs.
| CAT# | Product Name | Expression System | Protein Length | Solubilizing Agents |
| S01YF-1023-KX21 | NativeExtract™ Human AVPR2 Membrane Protein (Full length, Super Nanodisc) | HEK293 cell | Full length | Native Nanodisc |
| MPX4070K | MemDX™ Membrane Protein Human AVPR2 Expressed in vitro E.coli expression system, Full Length | E.coli cell-free | Full length | Detergent |
| Please for more products or customization | ||||
C***y: Ideal for renal research models requiring G-protein-coupled receptor accuracy.
08/Sep/2023
S***n: Tailored expression systems and purity specifications reduced our validation time by 40%.
13/Jun/2024
AVPR2 Gene Therapy Development
We provide tailored solutions to meet your specific requirements. Please for more services.
Correction of Gain-of-Function AVPR2 Mutations
Creative Biolabs offers correction of gain-of-function AVPR2 mutations services. Pathogenic AVPR2 variants, such as the R137C substitution, induce constitutive receptor activation, leading to nephrogenic syndrome of inappropriate antidiuresis (NSIAD). Gene editing systems enable precise genomic correction of these gain-of-function mutations in renal tubular epithelial cells. For example, homology-directed repair templates can replace mutant codons with wild-type sequences in patient-derived cell lines, normalizing cellular responses to osmotic stimuli. Creative Biolabs' proprietary screening platforms optimize guide RNA efficiency for clinical translation.
Adeno-Associated Virus (AAV)-Driven AVPR2 Silencing
Creative Biolabs offers AAV-driven AVPR2 silencing services. In cases of non-correctable variants, AAV vectors encoding short hairpin RNAs (shRNAs) achieve allele-specific AVPR2 knockdown. Preclinical murine models demonstrate that renal-selective AAV9 serotypes effectively transduce collecting duct cells, reducing aberrant aquaporin-2 trafficking and normalizing serum sodium levels within 14 days. Dose optimization studies by Creative Biolabs reveal persistent transgene expression for >6 months post-administration.
Creative Biolabs offers comprehensive and innovative services to drive the development of AVPR2 cell therapy. Please for more services.
Reconstitution of AVPR2 Signaling in Engineered Renal Progenitor Cells
Creative Biolabs offers reconstitution of AVPR2 signaling in engineered renal progenitor cells services. Patient-derived induced pluripotent stem cells (iPSCs) are differentiated into AVPR2-expressing renal progenitor cells using Wnt/β-catenin pathway agonists. Transplanted progenitors integrate into damaged nephrons in NSIAD models, restoring urinary concentrating capacity. Creative Biolabs' differentiation protocols achieve >85% AVPR2+ cell purity, validated via qPCR and calcium flux assays.
CAR-Macrophages for AVPR2 Overexpression Syndromes
Creative Biolabs offers CAR-macrophages development services for AVPR2 overexpression syndromes. CAR-macrophages engineered to detect AVPR2 hyperactivity via synthetic Notch receptors selectively degrade pathological renal cells in vitro. These cells secrete uroguanylin to counteract antidiuretic signaling, achieving a 60% reduction in intracellular cAMP in NSIAD patient organoids. Creative Biolabs' immune cell engineering platform supports rapid prototyping of receptor-targeted CAR systems.
Our end-to-end solutions—from gene editing optimization to GMP-compliant cell manufacturing—accelerate your NSIAD therapeutic pipeline. to discuss target validation, in vivo efficacy testing, or IND-enabling studies.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
