This product is a U266B1 [U266] B cell engineering tool based on the Magnetic nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-317-crRNA:tracrRNA duplex-Cas12-Brefeldin A ) genome editor.
| Host Cell | U266B1 [U266] |
| Target | ALPP |
| Insert Clone | 421CT8.1.1 |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Thymoquinone |
| Particle Size | <2500 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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