This product is a SKO-007 B cell engineering tool based on the Gold nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-RS-1 ) genome editor.
| Host Cell | SKO-007 |
| Target | BST2 |
| Insert Clone | BCX-R91 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <500 |
| Charge (mv) | −18 to -84 |
| Total Atom Count | ~65,000,000 |
| Surface Atoms (%) | ~0.6 |
| Specific Surface Area (m2/g) | ~0.8 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Non-small cell lung cancer; Prostate cancer; Liver cancer |
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