This product is a SU-DHL-8 B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-289-SpCas9-SpCas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | SU-DHL-8 |
| Target | DENV |
| Insert Clone | HMB-DV7 |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | SpCas9 |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 22-2410 |
| Charge (mv) | −2 to -31 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Brain cancer; Colon cancer; Ovarian cancer |
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