This product is a Toledo B cell engineering tool based on the Dendrimers (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (SHS-229-crispr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Toledo |
| Target | DENV |
| Insert Clone | HMB-DV9 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | crispr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Dendrimers |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | DOX |
| Particle Size | 22-500 |
| Charge (mv) | 1 to -31 |
| Total Atom Count | -23000000 |
| Surface Atoms (%) | -4 |
| Specific Surface Area (m2/g) | -7 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Breast cancer; Lung cancer; Brain cancer; Colon cancer; Ovarian cancer |
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