This product is a BC-2 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (huROSA-26-sgRNA-Cpf1-SCR7 pyrazine) genome editor.
| Host Cell | BC-2 |
| Target | EGFR |
| Insert Clone | BG-19A |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <500 |
| Charge (mv) | ≤50 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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