This product is a Ramos (RA 1) B cell engineering tool based on the Liposomes (Folate/ Folate Receptor) delivery system and CRISPR-based (huROSA-26-SpCas9-NLS-Cas9-Brefeldin A) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EGFR |
| Insert Clone | BG-30A |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Liposomes |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-3000 |
| Charge (mv) | 13 to 67 |
| Total Atom Count | -64000000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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