This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (SHS-227-tracr RNA-Cas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EGFR |
| Insert Clone | BG-18A |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 10-1000 |
| Charge (mv) | 8-55 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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