This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (CCR5-crispr RNA-SpCas9-Nocodazole) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EGFR |
| Insert Clone | BG-32A |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | < 0.5 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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