This product is a RPMI 1788 B cell engineering tool based on the Gold nanoparticles (EGFR mAb/Epidermal Growth Factor Receptor) delivery system and CRISPR-based (huROSA-26-crRNA:tracrRNA duplex-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | RPMI 1788 |
| Target | EGFR |
| Insert Clone | BG-21A |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | DOX |
| Particle Size | ≤10000 |
| Charge (mv) | -1 to -20 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Pancreatic cancer; Ovarian cancer; Breast cancer; Colon cancer |
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