This product is a SU-DHL-8 B cell engineering tool based on the Magnetic nanoparticles (Tumor-homing peptide tLyp-1/NRP-1) delivery system and CRISPR-based (hROSA26-SpCas9-NLS-Cas9-SCR7 pyrazine) genome editor.
| Host Cell | SU-DHL-8 |
| Target | EMC8 |
| Insert Clone | BGJ-3605CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | Tumor-homing peptide tLyp-1/NRP-1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-2850 |
| Charge (mv) | -5 to -75 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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