This product is a BC-2 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | BC-2 |
| Target | EMC8 |
| Insert Clone | BGX-2951CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Human genome |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-1000 |
| Charge (mv) | <-25 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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