This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-321-tracr RNA-Cas9-L755507) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | EMC8 |
| Insert Clone | CBFYC-2600CR |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | 10-50 |
| Charge (mv) | 13 to 65 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Liver cancer; Lung cancer; Colon cancer |
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