This product is a SU-DHL-4 B cell engineering tool based on the Gold nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-227-crispr RNA-SpCas9-SCR7 pyrazine) genome editor.
| Host Cell | SU-DHL-4 |
| Target | EphA2 |
| Insert Clone | 37.1D7CR |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <1660 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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