This product is a CA46 B cell engineering tool based on the Microbubbles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-sgRNA-Cpf1-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | CA46 |
| Target | EphA2 |
| Insert Clone | 53.2H11CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Microbubbles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Regorafenib |
| Particle Size | 10-50 |
| Charge (mv) | -25 to -125 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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