This product is a BC-2 B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-229-tracr RNA-Cas9-RS-1) genome editor.
| Host Cell | BC-2 |
| Target | EphA2 |
| Insert Clone | B6CR72 |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <100 |
| Charge (mv) | -18 to -84 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Colon cancer; Lung cancer; Brain cancer; Renal cancer; Leukemia |
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