This product is a BC-1 B cell engineering tool based on the Magnetic nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | BC-1 |
| Target | FAP |
| Insert Clone | B6CR255 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Regorafenib |
| Particle Size | <1000 |
| Charge (mv) | 6 to 86 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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