This product is a SKO-007 B cell engineering tool based on the Solid lipid nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (CCR5-SpCas9-SpCas9-Nocodazole) genome editor.
| Host Cell | SKO-007 |
| Target | FAP |
| Insert Clone | BCG-1435CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | SpCas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Mouse genome E-3 |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-50 |
| Charge (mv) | ≤50 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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