This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (AAVS1-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | FAP |
| Insert Clone | B6CR258 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-6 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-1000 |
| Charge (mv) | ≤50 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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