This product is a Raji B cell engineering tool based on the Sphingosomes (Folate/ Folate Receptor) delivery system and CRISPR-based (AAVS1-SpCas9-Cas9-(Z)-4-Hydroxytamoxifen ) genome editor.
| Host Cell | Raji |
| Target | FAP |
| Insert Clone | ESC14 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Sphingosomes |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | 20-3500 |
| Charge (mv) | −5 to -50 |
| Total Atom Count | ~60,000,000 |
| Surface Atoms (%) | ~0.8 |
| Specific Surface Area (m2/g) | ~2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Prostate cancer; Lung cancer; Ovarian cancer |
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