This product is a Raji B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cpf1-SCR7 pyrazine) genome editor.
| Host Cell | Raji |
| Target | FAP |
| Insert Clone | BCG-2140CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cpf1 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | 20-150 |
| Charge (mv) | -5 to -75 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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