This product is a BC-2 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-323-huIgH296-Cas12-RS-1) genome editor.
| Host Cell | BC-2 |
| Target | FAP |
| Insert Clone | B6CR256 |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | RS-1 |
| Targeting Strategy | pH-dependent |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <100 |
| Charge (mv) | -10 to -50 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Colon cancer |
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