This product is a CA46 B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-229-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | CA46 |
| Target | FKBP5 |
| Insert Clone | BCG-3053CR |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | Thymoquinone |
| Particle Size | <1660 |
| Charge (mv) | 0 to -30 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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