This product is a U266B1 [U266] B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (huROSA-26-huIgH296-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | U266B1 [U266] |
| Target | FLT1 |
| Insert Clone | BG-12F |
| Safe Harbor Sites (SHS) | huROSA-26 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <2300 |
| Charge (mv) | 15-60 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colon cancer |
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