This product is a Ramos (RA 1) B cell engineering tool based on the Solid lipid nanoparticles (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (CCR5-SpCas9-NLS-Cas9-Nocodazole) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | GM2 |
| Insert Clone | BG-67F |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive, time-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | <2300 |
| Charge (mv) | <-25 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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