This product is a NAMALWA B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-321-huIgH296-SpCas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | NAMALWA |
| Target | GM2 |
| Insert Clone | BG-71F |
| Safe Harbor Sites (SHS) | SHS-321 |
| gRNA | huIgH296 |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-1000 |
| Charge (mv) | -5 to -75 |
| Total Atom Count | -22,000,000 |
| Surface Atoms (%) | -3 |
| Specific Surface Area (m2/g) | -9 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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