This product is a SU-DHL-4 B cell engineering tool based on the Micelles (LRP-1 targeting peptide/Lipoprotein receptor-related protein-1) delivery system and CRISPR-based (AAVS1-tracr RNA-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | SU-DHL-4 |
| Target | GM2 |
| Insert Clone | BG-70F |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Micelles |
| Ligand/Receptor | LRP-1 targeting peptide/Lipoprotein receptor-related protein-1 |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 10-1000 |
| Charge (mv) | -8 to -55 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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