This product is a RPMI 8226 B cell engineering tool based on the Sphingosomes (Transferrin/Transferrin receptor) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-RS-1) genome editor.
| Host Cell | RPMI 8226 |
| Target | GM2 |
| Insert Clone | BG-69F |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | RS-1 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Sphingosomes |
| Ligand/Receptor | Transferrin/Transferrin receptor |
| Active Agents | Regorafenib |
| Particle Size | 15-188 |
| Charge (mv) | 10-93 |
| Total Atom Count | -57,000,000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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