This product is a Raji-Luc2 B cell engineering tool based on the Gold nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-323-crRNA:tracrRNA duplex-Cas12-SCR7 pyrazine) genome editor.
| Host Cell | Raji-Luc2 |
| Target | GM2 |
| Insert Clone | BG-68F |
| Safe Harbor Sites (SHS) | SHS-323 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-3000 |
| Charge (mv) | 10 to 55 |
| Total Atom Count | -64,000,000 |
| Surface Atoms (%) | -0.5 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | MSCV |
| Vector Name | BCpCDH6 |
| Targeting Diseases | Breast cancer; Lung cancer; Colorectal cancer |
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