This product is a Ramos (RA 1) B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial cell adhesion molecule) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | MIF |
| Insert Clone | BGC61 |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH-dependent |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | Celastrol |
| Particle Size | 41-3500 |
| Charge (mv) | <-27 |
| Total Atom Count | -57000000 |
| Surface Atoms (%) | -0.7 |
| Specific Surface Area (m2/g) | -3.6 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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