This product is a Ramos (RA 1) B cell engineering tool based on the Nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (hROSA26-crRNA:tracrRNA duplex-Cas12-Brefeldin A) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | MIF |
| Insert Clone | BGC63 |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | Brefeldin A |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | <2410 |
| Charge (mv) | −11 to -37 |
| Total Atom Count | -73000000 |
| Surface Atoms (%) | -0.6 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Adenoviruses |
| Vector Name | BCpCDH3 |
| Targeting Diseases | Lung cancer; Brain cancer; Colon cancer; Ovarian cancer; Liver cancer |
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