This product is a CA46 B cell engineering tool based on the Solid lipid nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (AAVS1-crispr RNA-SpCas9-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | CA46 |
| Target | NAE1 |
| Insert Clone | 1B2-CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive |
| Insertion sites | Human genome |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 20-2850 |
| Charge (mv) | 3 to 20 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Liver cancer |
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