This product is a RPMI 8226 B cell engineering tool based on the Gold nanoparticles (EGFR mAb/Epidermal GrowthFactor Receptor) delivery system and CRISPR-based (AAVS1-SpCas9-NLS-Cas9-RS-1) genome editor.
| Host Cell | RPMI 8226 |
| Target | NAE1 |
| Insert Clone | BCGW-0942CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Large DNA sequences |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EGFR mAb/Epidermal Growth Factor Receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 1-100 |
| Charge (mv) | -10 to -50 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Lung cancer; Liver cancer |
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