This product is a Ramos (RA 1) B cell engineering tool based on the Micelles (Folate/ Folate Receptor) delivery system and CRISPR-based (SHS-317-crRNA:tracrRNA duplex-SpCas9-SCR7 pyrazine) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NAE1 |
| Insert Clone | D9I4ZCR |
| Safe Harbor Sites (SHS) | SHS-317 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | SpCas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-4 |
| Vehicles | Micelles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Celastrol |
| Particle Size | <1000 |
| Charge (mv) | 0 to -16 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Lung cancer; Liver cancer |
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