This product is a SKO-007 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (SHS-229-sgRNA-Cpf1-3'-Azido-3'-deoxythymidine) genome editor.
| Host Cell | SKO-007 |
| Target | NDUFB11 |
| Insert Clone | 1D6CR |
| Safe Harbor Sites (SHS) | SHS-229 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | 3'-Azido-3'-deoxythymidine |
| Targeting Strategy | pH responsive, time-dependent |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | 10-50 |
| Charge (mv) | -15 to -185 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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