This product is a Ramos (RA 1) B cell engineering tool based on the Magnetic nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (AAVS1-sgRNA-Cpf1-RS-1) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NDUFB11 |
| Insert Clone | BCGW-1264CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | sgRNA |
| Nuclease | Cpf1 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Human genome |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Celastrol |
| Particle Size | 20-2850 |
| Charge (mv) | -1 to -20 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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