This product is a BC-3 B cell engineering tool based on the Microbubbles (Folate/ Folate Receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cas9-SCR7 pyrazine) genome editor.
| Host Cell | BC-3 |
| Target | NDUFB11 |
| Insert Clone | 9C5CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | SCR7 pyrazine |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Microbubbles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | Thymoquinone |
| Particle Size | <100 |
| Charge (mv) | <80 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Breast cancer; Colorectal cancer; Ovarian cancer; Non-small-cell lung cancer; Liver cancer |
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