This product is a RPMI 8226 B cell engineering tool based on the Microbubbles (SS-Fc/Carcinoembryonic antigen) delivery system and CRISPR-based (hROSA26-crispr RNA-SpCas9-L755507) genome editor.
| Host Cell | RPMI 8226 |
| Target | NEUROG3 |
| Insert Clone | 4F6CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | crispr RNA |
| Nuclease | SpCas9 |
| Enhancer | L755507 |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Mouse genome E-7 |
| Vehicles | Microbubbles |
| Ligand/Receptor | SS-Fc/Carcinoembryonic antigen |
| Active Agents | Regorafenib |
| Particle Size | 10-50 |
| Charge (mv) | ≤50 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | AAV |
| Vector Name | BCpCDH1 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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