This product is a CA46 B cell engineering tool based on the Liposomes (Hyaluronic acid/ RHAMM, CD44) delivery system and CRISPR-based (AAVS1-huIgH296-NLS-Cas9-RS-1) genome editor.
| Host Cell | CA46 |
| Target | NEUROG3 |
| Insert Clone | BCGW-0474CR |
| Safe Harbor Sites (SHS) | AAVS1 |
| gRNA | huIgH296 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Liposomes |
| Ligand/Receptor | Hyaluronic acid/ RHAMM, CD44 |
| Active Agents | Bortezomib |
| Particle Size | <1000 |
| Charge (mv) | -3 to -71 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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