This product is a Ramos (RA 1) B cell engineering tool based on the Magnetic nanoparticles (AS1411 aptamer/Nucleolin) delivery system and CRISPR-based (SHS-227-tracr RNA-Cas9-Nocodazole) genome editor.
| Host Cell | Ramos (RA 1) |
| Target | NEUROG3 |
| Insert Clone | 4F9CR |
| Safe Harbor Sites (SHS) | SHS-227 |
| gRNA | tracr RNA |
| Nuclease | Cas9 |
| Enhancer | Nocodazole |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Magnetic nanoparticles |
| Ligand/Receptor | AS1411 aptamer/Nucleolin |
| Active Agents | 5-Fluorouracil (5-FU) |
| Particle Size | <100 |
| Charge (mv) | 6 to 86 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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