This product is a GA-10 B cell engineering tool based on the Solid lipid nanoparticles (Dexamethasone/Glucocorticoid receptor) delivery system and CRISPR-based (SHS-255-SpCas9-NLS-Cas9-RS-1) genome editor.
| Host Cell | GA-10 |
| Target | SNAI1 |
| Insert Clone | BCGS-2933CR |
| Safe Harbor Sites (SHS) | SHS-255 |
| gRNA | SpCas9 |
| Nuclease | NLS-Cas9 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-5 |
| Vehicles | Solid lipid nanoparticles |
| Ligand/Receptor | Dexamethasone/Glucocorticoid receptor |
| Active Agents | AntimiR-21, doxorubicin (DOX) |
| Particle Size | 20-2850 |
| Charge (mv) | <80 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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