This product is a SU-DHL-10 B cell engineering tool based on the Nanoparticles (MUC1 aptamer/MUC1) delivery system and CRISPR-based (SHS-289-huIgH296-Cas12-Nocodazole) genome editor.
| Host Cell | SU-DHL-10 |
| Target | SNCG |
| Insert Clone | BCGS-0611CR |
| Safe Harbor Sites (SHS) | SHS-289 |
| gRNA | huIgH296 |
| Nuclease | Cas12 |
| Enhancer | Nocodazole |
| Targeting Strategy | pH responsive |
| Insertion sites | Mouse genome E-1 |
| Vehicles | Nanoparticles |
| Ligand/Receptor | MUC1 aptamer/MUC1 |
| Active Agents | Bortezomib |
| Particle Size | ≤900 |
| Charge (mv) | 3 to 20 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | Lentivirus |
| Vector Name | BCpCDH2 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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