This product is a SU-DHL-5 B cell engineering tool based on the Nanoparticles (Folate/ Folate Receptor) delivery system and CRISPR-based (CCR5-sgRNA-Cas9-Brefeldin A) genome editor.
| Host Cell | SU-DHL-5 |
| Target | SNCG |
| Insert Clone | BCGS-5486CR |
| Safe Harbor Sites (SHS) | CCR5 |
| gRNA | sgRNA |
| Nuclease | Cas9 |
| Enhancer | Brefeldin A |
| Targeting Strategy | pH-dependent |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Folate/ Folate Receptor |
| Active Agents | DOX |
| Particle Size | 10-500 |
| Charge (mv) | -5 to -50 |
| Total Atom Count | -33000000 |
| Surface Atoms (%) | -3.5 |
| Specific Surface Area (m2/g) | -5.5 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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