This product is a P3HR-1 B cell engineering tool based on the Nanoparticles (Mannose/Mannose receptor) delivery system and CRISPR-based (hROSA26-huIgH296-Cas9-(Z)-4-Hydroxytamoxifen) genome editor.
| Host Cell | P3HR-1 |
| Target | SNCG |
| Insert Clone | JM90-32CR |
| Safe Harbor Sites (SHS) | hROSA26 |
| gRNA | huIgH296 |
| Nuclease | Cas9 |
| Enhancer | (Z)-4-Hydroxytamoxifen |
| Targeting Strategy | pH responsive, mucoadhesiveness |
| Insertion sites | Nonhomologous target sites |
| Vehicles | Nanoparticles |
| Ligand/Receptor | Mannose/Mannose receptor |
| Active Agents | Regorafenib |
| Particle Size | 20-150 |
| Charge (mv) | -23 to -80 |
| Total Atom Count | -70000000 |
| Surface Atoms (%) | -0.8 |
| Specific Surface Area (m2/g) | -2.5 |
| Vector Type | MMLV |
| Vector Name | BCpCDH5 |
| Targeting Diseases | Ovarian cancer; Breast cancer; Pancreatic cancer |
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